Based on allometric scaling, the doses of EGCG observed to cause toxicity in the study (500 – 1500 mg/kg) correspond to a dose in humans of 30 – 90 mg/kg assuming a daily requirement of 12 and 2000 kcal for mice and humans, respectively (Schneider et al., 2004).Oct 31, 2009
How much EGCG is too much?
There is currently no clear dosage recommendation for EGCG, though 800 mg daily for up to 4 weeks has been used safely in studies. EGCG supplements have been linked to serious side effects and may interfere with medication absorption.
How much EGCG is safe per day?
A safe intake level of 338 mg EGCG/day for adults was derived from toxicological and human safety data for tea preparations ingested as a solid bolus dose. An Observed Safe Level (OSL) of 704 mg EGCG/day might be considered for tea preparations in beverage form based on human AE data.
How much green tea extract is toxic?
However, current evidence suggests that Vitamin A toxicity occurs with ingestion of greater than 40000 IU daily or about 12000 micrograms daily[11]. Our patient was taking 5000 IU three times per week, or only 15000 IU per week.
Is EGCG hard on liver?
Based on safety assessment of green tea products, the European Food Safety Authority recently found that green tea supplements providing more than 800 mg of EGCG per day are linked with a greater risk of liver injury. Keep in mind that this possible risk of liver injury relates to green tea EXTRACT.
Is 100 mg of green tea extract safe?
The recommended dose is 250–500 mg a day, and it's best taken with food. Amounts above this may be toxic. Plus, people with diabetes or those taking certain medications should speak with a healthcare professional before taking any amount of green tea extract.
How much EGCG is in Matcha?
It also appears to contain more EGCG. ConsumerLab.com, an independent testing group, tested matcha products in 2015 and found that matcha provided 17 mg to 109 mg of EGCG per serving. By comparison, the average brewed green tea provides 25 to 86 mg per serving.
Is 100mg of green tea extract safe?
The recommended dose is 250–500 mg a day, and it's best taken with food. Amounts above this may be toxic. Plus, people with diabetes or those taking certain medications should speak with a healthcare professional before taking any amount of green tea extract.